Nitroglycerine: Difference between revisions
Ostermayer (talk | contribs) (Text replacement - "Category:Drugs" to "Category:Pharmacology") |
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==Adult Dosing== | ==Adult Dosing== | ||
===Angina, acute=== | ===Angina, acute=== | ||
* 0.3 - 0.6 mg SL q5min, max: 3 doses within 15 min | *0.3 - 0.6 mg SL q5min, max: 3 doses within 15 min | ||
* IV form: 5 mcg/min IV, increase 5-20 mcg/min q3-5min. | *IV form: 5 mcg/min IV, increase 5-20 mcg/min q3-5min. | ||
===[[Hypertension]]=== | ===[[Hypertension]]=== | ||
| Line 27: | Line 27: | ||
==Contraindications== | ==Contraindications== | ||
*Allergy to class/drug | *Allergy to class/drug | ||
* pericardial tamponade | *pericardial tamponade | ||
* severe anemia | *severe anemia | ||
* SED use | *SED use | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
Revision as of 21:32, 4 July 2016
Administration
- Type: Vasodilator
- Dosage Forms: SL, IV
- Common Trade Names: Nitrostat
Adult Dosing
Angina, acute
- 0.3 - 0.6 mg SL q5min, max: 3 doses within 15 min
- IV form: 5 mcg/min IV, increase 5-20 mcg/min q3-5min.
Hypertension
- 5-200 mcg/min IV, start 5 mcg/min IV and increase increase 5 mcg/min q3-5min
Pediatric Dosing
HTN/CHF
- 1-5 mcg/kg/min IV
Special Populations
- Pregnancy Rating: C
- Lactation risk: safety unknown
Renal Dosing
- Adult: not defined
- Pediatric: not defined
Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- pericardial tamponade
- severe anemia
- SED use
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 1-3 min
- Metabolism: liver
- Excretion: urine
Mechanism of Action
- Stimulates cGMP production, resulting in vascular smooth muscle relaxtion