Nitroglycerine

Administration

  • Type: Vasodilator
  • Dosage Forms: SL, IV
  • Common Trade Names: Nitrostat

Adult Dosing

Angina, acute

  • 0.3 - 0.6mg SL q5min, max: 3 doses within 15 min
  • IV form: 5 mcg/min IV, increase 5-20 mcg/min q3-5min.

Hypertension

  • 5-200 mcg/min IV, start 5 mcg/min IV and increase increase 5 mcg/min q3-5min

Pediatric Dosing

hypertension/CHF

  • 1-5 mcg/kg/min IV

Special Populations

Renal Dosing

  • Adult: not defined
  • Pediatric: not defined

Hepatic Dosing

  • Adult: not defined
  • Pediatric: not defined

Contraindications

  • Allergy to class/drug
  • pericardial tamponade
  • severe anemia
  • SED use

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 1-3 min
  • Metabolism: liver
  • Excretion: urine

Mechanism of Action

  • Stimulates cGMP production, resulting in vascular smooth muscle relaxtion

Comments

See Also

References