Ivermectin: Difference between revisions

(Replace manual dosing with dynamic SMW tables)
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==Adult Dosing==
==Adult Dosing==
===[[Strongyloidiasis]]===
===Indications by Disease===
*0.2mg/kg PO x1
{{#ask: [[Has DrugName::Ivermectin]] [[Has Population::Adult]]
 
|?Treats disease=Disease
===[[Onchocerciasis]]===
|?Has Dose=Dose
*0.15mg/kg PO x1
|?Has Context=Context
 
|format=table
===[[Scabies]], non-crusted===
|limit=50
*0.2mg/kg PO x1
|mainlabel=-
 
|headers=show
===[[Scabies]], crusted===
|sort=Treats disease
*0.2mg/kg PO x1 on days 1,2,8,9,15
}}
 
===[[Pediculosis capitis]]===
*0.2mg/kg pO q10 days x2 doses
 
===[[Pediculosis corporis]]===
*12mg PO q7 days x3 doses
 
===[[Pediculosis pubis]]===
*0.25mg/kg PO q2wk x2 doses


==Pediatric Dosing==
==Pediatric Dosing==
===Indications by Disease===
{{#ask: [[Has DrugName::Ivermectin]] [[Has Population::Pediatric]]
|?Treats disease=Disease
|?Has Dose=Dose
|?Has Context=Context
|format=table
|limit=50
|mainlabel=-
|headers=show
|sort=Treats disease
}}


==Special Populations==
==Special Populations==

Revision as of 01:54, 20 March 2026

General

  • Type: antiparasitic
  • Dosage Forms: Tablet, 3mg
  • Common Trade Names: Stromectol

Adult Dosing

Indications by Disease

DiseaseDoseContext
Onchocerciasis0.15mg/kg PO x1Onchocerciasis
Scabies200mcg/kg PO repeat in 2wksSevere infection
Strongyloides stercoralis0.2mg/kg PO x1Strongyloidiasis

Pediatric Dosing

Indications by Disease

DiseaseDoseContext
Scabies200mcg/kg PO, repeat in 2 weeks; only for children >15kgPediatric Severe (>15kg)

Special Populations

  • Pregnancy Rating: C
  • Lactation: Safety Unknown
  • Renal Dosing- not defined
  • Hepatic Dosing- not defined

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

  • pruritus
  • rash
  • fever
  • edema
  • lymphadenopathy
  • headache
  • myalgia
  • dizziness
  • tachycardia
  • abnormal eye sensation
  • limbitis
  • conjunctivitis
  • ocular inflammation
  • hypotension, orthostatic
  • ALT, AST elevated
  • eosinophilia

Pharmacology

  • Half-life: 18h
  • Metabolism: liver, CYP450: unknown
  • Excretion: feces primarily, urine < 1%
  • Mechanism of Action: increases invertebrate nerve and muscle cell membrane permeability by binding to chloride ion channels, resulting in paralysis and death of parasite

See Also

References