Losartan: Difference between revisions
| Line 24: | Line 24: | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*Acute kidney injury | *[[Acute kidney injury]] | ||
* | *[[Rhabdomyolysis]] | ||
*Syncope | *[[Syncope]] | ||
*Stroke | *[[Stroke]] | ||
*Angioedema | *[[Angioedema]] | ||
===Common=== | ===Common=== | ||
*Backache | *[[Backache]] | ||
*Dizziness | *[[Dizziness]] | ||
*Cough, URI symptoms | *[[Cough]], [[URI]] symptoms | ||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 20:27, 29 September 2016
Administration
- Type: Antihypertensive, ARB
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Cozaar
Adult Dosing
Hypertension
- 25-150mg PO daily
Pediatric Dosing
- 0.1 to 1.4 mg/kg daily
Special Populations
- Pregnancy Rating: D
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: starting dose 25mg daily
Contraindications
- Allergy to class/drug
- Concomitant use with aliskiren in diabetes
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 2-6 hours
- Metabolism: Hepatic;P450 CYP2C9 and CYP3A4
- Excretion: Fecal, renal
Mechanism of Action
- Reversible angiotensin II inhibitor