Losartan: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
===[[Hypertension]]=== | |||
*25-150mg PO daily | *25-150mg PO daily | ||
Revision as of 20:26, 29 September 2016
Administration
- Type: Antihypertensive, ARB
- Dosage Forms:
- Routes of Administration: oral
- Common Trade Names: Cozaar
Adult Dosing
Hypertension
- 25-150mg PO daily
Pediatric Dosing
- 0.1 to 1.4 mg/kg daily
Special Populations
- Pregnancy Rating: D
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing: no adjustment
- Hepatic dosing: starting dose 25mg daily
Contraindications
- Allergy to class/drug
- Concomitant use with aliskiren in diabetes
Adverse Reactions
Serious
- Acute kidney injury
- Rhabdomyolisis
- Syncope
- Stroke
- Angioedema
Common
- Backache
- Dizziness
- Cough, URI symptoms
Pharmacology
- Half-life: 2-6 hours
- Metabolism: Hepatic;P450 CYP2C9 and CYP3A4
- Excretion: Fecal, renal
Mechanism of Action
- Reversible angiotensin II inhibitor