Tigecycline: Difference between revisions
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==Special Populations== | ==Special Populations== | ||
*[[Drug Ratings in Pregnancy|Drug rating in pregnancy]]: | *[[Drug Ratings in Pregnancy|Drug rating in pregnancy]]: | ||
*[[Lactation_risk_categories|Lactation risk category]] | *[[Lactation_risk_categories|Lactation risk category]]: Possibly Unsafe; consider alternatives | ||
*Renal Dosing | *Renal Dosing | ||
**Adult: | **Adult: | ||
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*Jarisch-Herxheimer reaction | *Jarisch-Herxheimer reaction | ||
*Fetal harm | *Fetal harm | ||
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===Common=== | ===Common=== | ||
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*Skin discoloration | *Skin discoloration | ||
*Elevated BUN | *Elevated BUN | ||
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==Pharmacology== | ==Pharmacology== | ||
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{{Template:Antibacterial Spectra Key}} | {{Template:Antibacterial Spectra Key}} | ||
==See Also== | ==See Also== | ||
*[[Antibiotics (Main)]] | |||
==Source== | ==Source== | ||
Revision as of 12:31, 30 March 2016
General
- Type: Glycylcycline (Tetracyclines)
- Dosage Forms:
- Common Trade Names: Tygacil
Adult Dosing
General Infections
Pediatric Dosing
General Infections
Special Populations
- Drug rating in pregnancy:
- Lactation risk category: Possibly Unsafe; consider alternatives
- Renal Dosing
- Adult:
- Pediatric:
- Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
- Pregnancy
- Age <8 years
- Caution:
- Child bearing potential
Adverse Reactions
Serious
- Tooth discoloration children <8 years old
- Photosensitivity
- Hypersensitivity reaction
- Skin reaction
- Vasculitis
- Pericarditis
- Autoimmune hepatitis
- Hepatotoxicity
- Nephrotoxicity
- Esophagitis/ulcer
- Pancreatitis
- Thrombocytopenia
- Neutropenia
- Hemolytic anemia
- Pseudotumor cerebri
- Bulging fontanelles
- Jarisch-Herxheimer reaction
- Fetal harm
Common
- Headache
- Nausea
- Dyspepsia
- Arthralgia
- Diarrhea
- Rash
- Dysmenorrhea
- Photosensitivity
- Vulvovaginal candidiasis
- Skin discoloration
- Elevated BUN
Pharmacology
- Half-life:
- Metabolism:
- Excretion: Feces and urine
- Mechanism of Action: Bacteriostatic
Antibiotic Sensitivities[1]
Key
- S susceptible/sensitive (usually)
- I intermediate (variably susceptible/resistant)
- R resistant (or not effective clinically)
- S+ synergistic with cell wall antibiotics
- U sensitive for UTI only (non systemic infection)
- X1 no data
- X2 active in vitro, but not used clinically
- X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
- X4 active in vitro, but not clinically effective for strep pneumonia
See Also
Source
- ↑ Sanford Guide to Antimicrobial Therapy 2014