Pheochromocytoma: Difference between revisions
(created page on pheochromocytoma) |
Neil.m.young (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
==Background== | ==Background== | ||
* | *Rare tumor arising from chromaffin cells in adrenal medulla or other paraganglia in the body | ||
* | *Increased catecholamine production leading to its clinical manifestations | ||
==Clinical Features== | ==Clinical Features== | ||
* | *Headache | ||
* | *Alternating periods of normal and elevated blood pressure, and can cause resistant hypertension and hypertensive emergency | ||
* | *Tachycardia | ||
* | *Flushed skin | ||
* | *Palpitations | ||
* | *Diaphoresis | ||
* | *Weight loss | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
{{Hypertension DDX}} | |||
==Diagnosis== | ==Diagnosis== | ||
* | *Plasma free metanephrines | ||
* CT imaging to localize tumor | *Urinary fractionated metanephrines | ||
* | *CT imaging to localize tumor | ||
*General lab features include hyperglycemia, hypercalcemia, and erythrocytosis | |||
==Management== | ==Management== | ||
* | *Alpha blockade with phenoxybenzamine or phentolamine acutely | ||
* | *Beta blockade can be started 2 days later | ||
* | *Eventual surgical resection of tumor | ||
==Disposition== | ==Disposition== | ||
* | *Admission to a monitored setting | ||
==See Also== | ==See Also== | ||
*[[Hypertensive emergency]] | |||
==External Links== | ==External Links== | ||
==References== | ==References== | ||
<references\> | |||
*1. Garg, M., Brar, K., Mittal, R., Kharb, S., & Gundgurthi, A. (2011). Medical management of pheochromocytoma: Role of the endocrinologist. Indian Journal Of Endocrinology And Metabolism, 15(8), 329. http://dx.doi.org/10.4103/2230-8210.86976 | *1. Garg, M., Brar, K., Mittal, R., Kharb, S., & Gundgurthi, A. (2011). Medical management of pheochromocytoma: Role of the endocrinologist. Indian Journal Of Endocrinology And Metabolism, 15(8), 329. http://dx.doi.org/10.4103/2230-8210.86976 | ||
*2. WJ Elliott, J Varon. Drugs used for the treatment of hypertensive emergencies. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed on January 11, 2016.) | *2. WJ Elliott, J Varon. Drugs used for the treatment of hypertensive emergencies. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed on January 11, 2016.) | ||
*3. DM Cline, AJ Machado (2015). "Systemic and Pulmonary Hypertension." Tintinalli's Emergency Medicine. Mcgraw-Hill Education. | *3. DM Cline, AJ Machado (2015). "Systemic and Pulmonary Hypertension." Tintinalli's Emergency Medicine. Mcgraw-Hill Education. | ||
*4. Pheochromocytoma. (n.d.). In Wikipedia. Retrieved January 11, 2016, from http://en.wikipedia.org/wiki/pheochromocytoma | *4. Pheochromocytoma. (n.d.). In Wikipedia. Retrieved January 11, 2016, from http://en.wikipedia.org/wiki/pheochromocytoma | ||
Revision as of 12:35, 12 January 2016
Background
- Rare tumor arising from chromaffin cells in adrenal medulla or other paraganglia in the body
- Increased catecholamine production leading to its clinical manifestations
Clinical Features
- Headache
- Alternating periods of normal and elevated blood pressure, and can cause resistant hypertension and hypertensive emergency
- Tachycardia
- Flushed skin
- Palpitations
- Diaphoresis
- Weight loss
Differential Diagnosis
Hypertension
- Hypertensive emergency
- Stroke
- Sympathetic crashing acute pulmonary edema
- Ischemic stroke
- Intracranial hemorrhage
- Preeclampsia/Eclampsia
- Autonomic dysreflexia
- Scleroderma renal crisis
- Acute glomerulonephritis
- Type- I myocardial infarction
- Volume overload
- Urinary obstruction
- Drug use or overdose (e.g stimulants, especially alcohol, cocaine, or Synthroid)
- Renal Artery Stenosis
- Nephritic and nephrotic syndrome
- Polycystic kidney disease
- Tyramine reaction
- Cushing's syndrome
- Obstructive sleep apnea
- Pheochromocytoma
- Hyperaldosteronism
- Hyperthyroidism
- Anxiety
- Pain
- Oral contraceptive use
Diagnosis
- Plasma free metanephrines
- Urinary fractionated metanephrines
- CT imaging to localize tumor
- General lab features include hyperglycemia, hypercalcemia, and erythrocytosis
Management
- Alpha blockade with phenoxybenzamine or phentolamine acutely
- Beta blockade can be started 2 days later
- Eventual surgical resection of tumor
Disposition
- Admission to a monitored setting
See Also
External Links
References
<references\>
- 1. Garg, M., Brar, K., Mittal, R., Kharb, S., & Gundgurthi, A. (2011). Medical management of pheochromocytoma: Role of the endocrinologist. Indian Journal Of Endocrinology And Metabolism, 15(8), 329. http://dx.doi.org/10.4103/2230-8210.86976
- 2. WJ Elliott, J Varon. Drugs used for the treatment of hypertensive emergencies. In: UpToDate, Post TW (Ed), UpToDate, Waltham, MA. (Accessed on January 11, 2016.)
- 3. DM Cline, AJ Machado (2015). "Systemic and Pulmonary Hypertension." Tintinalli's Emergency Medicine. Mcgraw-Hill Education.
- 4. Pheochromocytoma. (n.d.). In Wikipedia. Retrieved January 11, 2016, from http://en.wikipedia.org/wiki/pheochromocytoma