Template:Sedative agents: Difference between revisions
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*Etomidate 0.15mg/kg (8-10mg avg) | *Etomidate 0.15mg/kg (8-10mg avg) | ||
**Wears off in 6min | **Wears off in 6min | ||
===Brevital (Methohexital)=== | |||
*Suppress the reticular activating center in the brainstem and cerebral cortex, thereby causing sedation | |||
*Sedation and amnesia, no analgesia | |||
*Dose fentanyl first: 0.5-1mcg/kg | |||
*Initial dose 0.75 to 1mg/kg IV | |||
*Repeat doses of 0.5mg/kg IV can be given every two minutes. | |||
*Immediate onset, duration <10 minutes | |||
===Propofol/Ketamine (Ketofol)=== | ===Propofol/Ketamine (Ketofol)=== | ||
Revision as of 20:57, 28 October 2015
Sedative agents
- Propofol
- Opioids
- Benzodiazepines
- Dexmedetomidine
- Ketamine
- Haloperidol and other tranquilizers
Fentanyl/Versed
- Designed for moderate sedation
- If titrate to deep sedation, when painful stimulus stops may become apneic
- Duration = 30min
Etomidate/Fentanyl
- Similar to versed/fentanyl but better b/c of shorter duration of action
- Good for brief sedation if don't have access to propofol
- E.g. shoulder/hip reduction, cardioversion
- Dose fentanyl first: 0.5-1mcg/kg
- Etomidate 0.15mg/kg (8-10mg avg)
- Wears off in 6min
Brevital (Methohexital)
- Suppress the reticular activating center in the brainstem and cerebral cortex, thereby causing sedation
- Sedation and amnesia, no analgesia
- Dose fentanyl first: 0.5-1mcg/kg
- Initial dose 0.75 to 1mg/kg IV
- Repeat doses of 0.5mg/kg IV can be given every two minutes.
- Immediate onset, duration <10 minutes
Propofol/Ketamine (Ketofol)
- 1:1 mixture of ketamine and propofol[1]
- Theorized that side-effect profiles counter one another
- Dose: 0.5mg/kg propofol with 0.5mg/kg ketamine (may be mixed in same syringe)
- ↑ Andolfatto G, Abu-Laban RB, Zed PJ, et al. Ketamine-propofol combination (ketofol) versus propofol alone for emergency department procedural sedation and analgesia: a randomized double-blind trial. Ann Emerg Med. 2012; 59(6): 504-12.e1-2. PMID: 22401952