Lorazepam

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General

  • Type: Benzodiazepine
  • Dosage Forms: Tablet: 0.5, 1, 2 mg. IV solution: 2mg/ml, 4 mg/ml
  • Common Trade Names: Ativan

Adult Dosing

Pediatric Dosing

Seizure

  • 0.1 mg/kg IV

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug
  • respiratory depression

Adverse Reactions

Serious

  • Respiratory depression
  • apnea
  • hypotension
  • paradoxical CNS stimulation

Common

  • sedation
  • ataxia
  • disinhibition
  • dysarthria

Pharmacology

  • Half-life: 10-20 hours
  • Metabolism: liver
  • Excretion: renal
  • Mechanism of Action: GABA receptor agonist

See Also

References