Non-Hodgkin's lymphoma: Difference between revisions
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==Clinical Features== | ==Clinical Features== | ||
*[[Lymphadenopathy]] | *[[Lymphadenopathy]] | ||
*Hepatosplenomegaly | *[[hepatomegaly|Hepatosplenomegaly]] | ||
*"B" symptoms ([[fever]], night sweats, weight loss) | *"B" symptoms ([[fever]], night sweats, weight loss) | ||
*GI: [[GI bleed]], [[intussusception]], [[nausea/vomiting]] | *GI: [[GI bleed]], [[intussusception]], [[nausea/vomiting]] | ||
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==Evaluation== | ==Evaluation== | ||
*CBC | *CBC | ||
*BMP, LFTs, uric acid | *BMP, [[LFTs]], uric acid | ||
*[[CXR]] | *[[CXR]] | ||
Revision as of 17:08, 1 October 2019
Background
- Can originate in lymphatic system or any organ in the body
- Occurs in children >5 years old
- Immunosuppression (e.g. HIV, crohn's, chemotherapy) is a risk factor
Clinical Features
- Lymphadenopathy
- Hepatosplenomegaly
- "B" symptoms (fever, night sweats, weight loss)
- GI: GI bleed, intussusception, nausea/vomiting
- Signs/symptoms of complications:
- Superior vena cava syndrome
- Pleural effusion, pericardial effusion
- Malignant cord compression
- Tumor lysis syndrome (rare in absence of active treatment)
Differential Diagnosis
Cervical Lymphadenopathy
- Hodgkin's lymphoma
- Non-Hodgkin's lymphoma
- Mononucleosis
- Toxoplasmosis
- Branchial cleft lesions
- Cat scratch disease
- Mycobacterial adenitis
Acute Leukemia/Lymphoma
Evaluation
Management
See management sections of specific complications:
- Superior vena cava syndrome
- Pleural effusion, pericardial effusion
- Malignant cord compression
- Tumor lysis syndrome
- Neutropenic fever
- Nausea/vomiting
- GI bleeding, intussusception