Grey baby syndrome: Difference between revisions

Latest revision as of 22:02, 5 October 2019

A side effect of chloramphenicol affecting newborns of mothers who have been exposed to the drug
Thought to be related to insufficient ability of the newborn's liver to metabolize the drug, as well as insufficient renal excretion

THE MISFITS ^[1]

↑ Brousseau T, Sharieff GQ. Newborn emergencies: the first 30 days of life. Pediatr Clin North Am. 2006 Feb;53(1):69-84, vi.

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 ==Background==
-Grey baby syndrome is a side effect of chloramphenicol affecting newborns of mothers who have been exposed to the drug. Symptoms usually occur within 1 week of exposure, and include an ashen gray color of the skin (hence the name), failure to thrive, poor appetite, vomiting, hypotension, hypothermia. The cause of grey baby syndrome is thought to be related to insufficient ability of the newborn's liver to metabolize the drug, as well as insufficient renal excretion.
+*A side effect of [[chloramphenicol]] affecting newborns of mothers who have been exposed to the drug
+*Thought to be related to insufficient ability of the newborn's liver to metabolize the drug, as well as insufficient renal excretion
 ==Clinical Features==
+*Symptoms usually occur within 1 week of exposure and include:
+**Ashen gray color of the skin
+**[[failure to thrive (peds)|Failure to thrive]]
+**Poor appetite
+**[[nausea and vomiting (peds)|Vomiting]]
+**[[Hypotension]]
+**[[Hypothermia]]
 ==Differential Diagnosis==
+{{Sick neonate DDX}}
 ==Evaluation==
+*Assess for alternate diagnoses
 ==Management==
+*Stop [[chloramphenicol]] exposure
+*[[Exchange transfusion]]
+*Sometimes [[phenobarbital]] used for UGT induction
 ==Disposition==
+*Admit
 ==See Also==