IV nitroglycerine alternatives: Difference between revisions

 
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*Suggestions for substitution during the IV shortage
*Suggestions for substitution during the IV shortage


===Nitroglycerine Bioavailability===
===[[Nitroglycerine]] Bioavailability===
*Oral <ref name="availability">http://sepia.unil.ch/pharmacology/index.php?id=51</ref>:    <1%
*Oral <ref name="availability">http://sepia.unil.ch/pharmacology/index.php?id=51</ref>:    <1%
*Sublingual <ref name="availability"/>: 38% (15-40%)
*Sublingual <ref name="availability"/>: 38% (15-40%)
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==Suggested Substitutions<ref>http://www.medpagetoday.com/EmergencyMedicine/EmergencyMedicine/45056</ref>==
==Suggested Substitutions<ref>http://www.medpagetoday.com/EmergencyMedicine/EmergencyMedicine/45056</ref>==
#Sublingual nitroglycerin, 1-2 tabs or sprays every 5 minutes as needed
*Sublingual nitroglycerin, 1-2 tabs or sprays every 5 minutes as needed
##Once controlled
**Once controlled
###Nitropursside '''OR''' Isordil PO (nitro paste or longer acting NTG)
***[[Nitroprusside]] '''OR''' [[Isordil]] PO (nitro paste or longer acting NTG)
##If not well controlled
**If not well controlled
###IV enalapril 0.625-1.25mg IV bolus
***IV [[enalapril]] 0.625-1.25mg IV bolus
###IV hydralazine 5-10mg IV bolus
***IV [[hydralazine]] 5-10mg IV bolus
###IV nitropursside
***IV [[nitroprusside]]


==See Also==
==See Also==
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<references>
<references>


[[Category:Drugs]]
[[Category:Pharmacology]]
[[Category:Cardiology]]

Latest revision as of 20:51, 22 September 2019

Background

  • Suggestions for substitution during the IV shortage

Nitroglycerine Bioavailability

  • Oral [1]: <1%
  • Sublingual [1]: 38% (15-40%)
  • Topical [1]: 72%

Half-life[2]: 0.05 h

Suggested Substitutions[3]

See Also

References

<references>