Nitroglycerine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
Angina, acute | ===Angina, acute=== | ||
* 0.3 - 0.6 mg SL q5min, max: 3 doses within 15 min | * 0.3 - 0.6 mg SL q5min, max: 3 doses within 15 min | ||
* IV form: 5 mcg/min IV, increase 5-20 mcg/min q3-5min. | * IV form: 5 mcg/min IV, increase 5-20 mcg/min q3-5min. | ||
===[[Hypertension]]=== | |||
*5-200 mcg/min IV, start 5 mcg/min IV and increase increase 5 mcg/min q3-5min | *5-200 mcg/min IV, start 5 mcg/min IV and increase increase 5 mcg/min q3-5min | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===HTN/CHF=== | |||
HTN/CHF | |||
*1-5 mcg/kg/min IV | *1-5 mcg/kg/min IV | ||
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==Adverse Reactions== | ==Adverse Reactions== | ||
===Serious=== | ===Serious=== | ||
*hypotension | *[[hypotension]] | ||
*bradycardia | *[[bradycardia]] | ||
*methemoglobinemia | *[[methemoglobinemia]] | ||
===Common=== | ===Common=== | ||
*headache | *[[headache]] | ||
*lightheadedness | *lightheadedness | ||
*dizziness | *[[dizziness]] | ||
*flushing | *flushing | ||
*reflex tachycardia | *reflex tachycardia | ||
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==Mechanism of Action== | ==Mechanism of Action== | ||
Stimulates cGMP production, resulting in vascular smooth muscle relaxtion | *Stimulates cGMP production, resulting in vascular smooth muscle relaxtion | ||
==Comments== | ==Comments== | ||
Revision as of 17:49, 3 December 2015
Administration
- Type: Vasodilator
- Dosage Forms: SL, IV
- Common Trade Names: Nitrostat
Adult Dosing
Angina, acute
- 0.3 - 0.6 mg SL q5min, max: 3 doses within 15 min
- IV form: 5 mcg/min IV, increase 5-20 mcg/min q3-5min.
Hypertension
- 5-200 mcg/min IV, start 5 mcg/min IV and increase increase 5 mcg/min q3-5min
Pediatric Dosing
HTN/CHF
- 1-5 mcg/kg/min IV
Special Populations
- Pregnancy Rating: C
- Lactation risk: safety unknown
Renal Dosing
- Adult: not defined
- Pediatric: not defined
Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- pericardial tamponade
- severe anemia
- SED use
Adverse Reactions
Serious
Common
Pharmacology
- Half-life: 1-3 min
- Metabolism: liver
- Excretion: urine
Mechanism of Action
- Stimulates cGMP production, resulting in vascular smooth muscle relaxtion