Nitroglycerine: Difference between revisions
(Created page with "==Administration== *Type: Vasodilator *Dosage Forms: SL, IV *Common Trade Names: Nitrostat ==Adult Dosing== Angina, acute * 0.3 - 0.6 mg SL q5min, max: 3 doses within 15 min...") |
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==See Also== | ==See Also== | ||
*[[IV nitroglycerine alternatives]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||
[[Category:Drugs]] | [[Category:Drugs]] | ||
Revision as of 14:29, 2 December 2015
Administration
- Type: Vasodilator
- Dosage Forms: SL, IV
- Common Trade Names: Nitrostat
Adult Dosing
Angina, acute
- 0.3 - 0.6 mg SL q5min, max: 3 doses within 15 min
- IV form: 5 mcg/min IV, increase 5-20 mcg/min q3-5min.
HTN
- 5-200 mcg/min IV, start 5 mcg/min IV and increase increase 5 mcg/min q3-5min
Pediatric Dosing
HTN/CHF
- 1-5 mcg/kg/min IV
Special Populations
- Pregnancy Rating: C
- Lactation risk: safety unknown
Renal Dosing
- Adult: not defined
- Pediatric: not defined
Hepatic Dosing
- Adult: not defined
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- pericardial tamponade
- severe anemia
- SED use
Adverse Reactions
Serious
- hypotension
- bradycardia
- methemoglobinemia
Common
- headache
- lightheadedness
- dizziness
- flushing
- reflex tachycardia
- edema
Pharmacology
- Half-life: 1-3 min
- Metabolism: liver
- Excretion: urine
Mechanism of Action
Stimulates cGMP production, resulting in vascular smooth muscle relaxtion