Penicillin G Benzathine: Difference between revisions

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==Adult Dosing==
==Adult Dosing==
===[[Streptococcal pharyngitis]]===
===[[Streptococcal pharyngitis]]===
*1.2 million units IM x 1
*1.2 million units IM x 1<ref>CDC Website, accessed 2026-28-01. https://www.cdc.gov/group-a-strep/hcp/clinical-guidance/strep-throat.html</ref>


===[[Syphilis]]===
===[[Syphilis]]===
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===Rheumatic Fever Prophylaxis, Secondary===
===Rheumatic Fever Prophylaxis, Secondary===
*1.2 million units IM every 4 weeks
*1.2 million units IM every 4 weeks
===Indications by Disease===
{{#ask: [[Has DrugName::Penicillin G Benzathine]] [[Has Population::Adult]]
|?Treats disease=Disease
|?Has Dose=Dose
|?Has Context=Context
|format=table
|limit=50
|mainlabel=-
|headers=show
|sort=Treats disease
}}


==Pediatric Dosing==
==Pediatric Dosing==
===Indications by Disease===
{{#ask: [[Has DrugName::Penicillin G Benzathine]] [[Has Population::Pediatric]]
|?Treats disease=Disease
|?Has Dose=Dose
|?Has Context=Context
|format=table
|limit=50
|mainlabel=-
|headers=show
|sort=Treats disease
}}
===[[Strep Pharyngitis]]===
===[[Strep Pharyngitis]]===
*'''<27kg:''' 0.6 million units IM x 1
*<27kg: 0.6 million units IM x 1<ref>CDC Website, accessed 2026-28-01. https://www.cdc.gov/group-a-strep/hcp/clinical-guidance/strep-throat.html</ref>
*'''>27kg:''' 1.2 million units IM x 1
*>27kg: 1.2 million units IM x 1<ref>CDC Website, accessed 2026-28-01. https://www.cdc.gov/group-a-strep/hcp/clinical-guidance/strep-throat.html</ref>


===[[Syphilis]]===
===[[Syphilis]]===
*'''Congenital (<1mo)'''
*Congenital (<1mo)
**50,000 units/kg IM x 1
**50,000 units/kg IM x 1
**Max: 2.4 million units/dose
**Max: 2.4 million units/dose
**Info: For asymptomatic disease only
**Info: For asymptomatic disease only
*'''Acquired'''
*Acquired
**Primary, secondary, or latent <1yr
**Primary, secondary, or latent <1yr
***50,000 units/kg IM x 1
***50,000 units/kg IM x 1
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===Rheumatic Fever Prophylaxis, Secondary===
===Rheumatic Fever Prophylaxis, Secondary===
*'''<27kg:''' 0.6 million units IM every 4 weeks
*<27kg: 0.6 million units IM every 4 weeks
*'''>27kg:''' 1.2 million units IM every 4 weeks
*>27kg: 1.2 million units IM every 4 weeks


==Special Populations==
==Special Populations==
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[[Category:Pharmacology]]
[[Category:Pharmacology]]
[[Category:ID]]

Latest revision as of 09:13, 22 March 2026

General

Adult Dosing

Streptococcal pharyngitis

  • 1.2 million units IM x 1[1]

Syphilis

  • Primary, secondary, or latent <1yr
    • 2.4 million units IM x 1
  • Latent >1yr or unknown duration, or tertiary
    • 2.4 million units IM qWeek x 3 weeks
  • Neurosyphilis
    • 4 million units IV Q4H x10 days

Rheumatic Fever Prophylaxis, Secondary

  • 1.2 million units IM every 4 weeks

Indications by Disease

DiseaseDoseContext
Streptococcal pharyngitis<27 kg: 0.6 million units; ≥27 kg: 1.2 million units IM x 1Penicillin Options
Syphilis2.4 million units IM x 1Early Stage
Syphilis2.4 million units IM weekly x 3 weeksLate Stage

Pediatric Dosing

Indications by Disease

DiseaseDoseContext
Streptococcal pharyngitis<27kg: 600,000 units IM x 1; >27kg: 1.2 million units IM x 1Pediatric First Line
Syphilis50,000 units/kg IM x 1Congenital, maternal treatment adequate
Syphilis50,000 units/kg IM x 1 (max 2.4 million units)Pediatric Early Stage

Strep Pharyngitis

  • <27kg: 0.6 million units IM x 1[2]
  • >27kg: 1.2 million units IM x 1[3]

Syphilis

  • Congenital (<1mo)
    • 50,000 units/kg IM x 1
    • Max: 2.4 million units/dose
    • Info: For asymptomatic disease only
  • Acquired
    • Primary, secondary, or latent <1yr
      • 50,000 units/kg IM x 1
      • Max: 2.4 million units/dose
    • Latent >1yr or unknown duration
      • 50,000 units/kg IM qWeek x 3 weeks
      • Max: 2.4 million units/dose

Rheumatic Fever Prophylaxis, Secondary

  • <27kg: 0.6 million units IM every 4 weeks
  • >27kg: 1.2 million units IM every 4 weeks

Special Populations

  • Pregnancy Rating: B
  • Lactation: Safe
  • Renal Dosing
    • Adult
      • CrCl 10-50: decrease dose 25%
      • CrCl <10: decrease dose 50-80%
      • Hemodialysis: give after dialysis without supplement
      • Peritoneal Dialysis: decrease dose 50-80%
    • Pediatric
      • CrCl 10-50: decrease dose 25%
      • CrCl <10: decrease dose 50-80%
      • Hemodialysis: give supplement
  • Hepatic Dosing (Adult & Pediatric)
    • No data

Black Box

  • Do not administer IV or mix with IV solutions (associated with cardiopulmonary arrest)

Contraindications

Cautions

  • Non-anaphylactic reaction to Beta Lactams
  • Hypersensitivity to multiple compounds
  • Asthma
  • Recent antibiotic associated colitis
  • Seizure disorder
  • Renal imparement

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: Unknown
  • Metabolism: liver, CYP450
  • Excretion: Urine
  • Mechanism of Action: Bactericidal

See Also

References

  1. ↑ CDC Website, accessed 2026-28-01. https://www.cdc.gov/group-a-strep/hcp/clinical-guidance/strep-throat.html
  2. ↑ CDC Website, accessed 2026-28-01. https://www.cdc.gov/group-a-strep/hcp/clinical-guidance/strep-throat.html
  3. ↑ CDC Website, accessed 2026-28-01. https://www.cdc.gov/group-a-strep/hcp/clinical-guidance/strep-throat.html
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