- Uncomfortable, damaging, and sometimes fatal reactions produced by the normal immune system including allergies and autoimmunity.
|I: Allergy, Immediate||IgE-mediated degranulation of mast cells and basophils; usually happens after a first exposure which causes sensitization||Urticaria, anaphylaxis, angioedema|
|II: Cytotoxic, Antibody Dependant||IgG or IgM antibodies react with cell antigens with resultant complement activation||Myasthenia gravis, goodpasture syndrome, erythroblastalis fetalis, AI hemolytic anemia, Graves disease|
|III: Immune Complex||IgG immune complex deposition and subsequent complement activation||Serum sickness, RA, SLE, post-strep glomerularnephritis|
|IV: Cell-mediated, Delayed||Activated T cells against cell surface antigens||TB skin test, chronic transplant rejection, contact dermatitis|