Diethylcarbamazine: Difference between revisions
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==Adult Dosing== | ==Adult Dosing== | ||
[[Lymphatic filariasis]] | ===[[Lymphatic filariasis]]=== | ||
*''including lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori'' | *''including lymphatic filariasis caused by infection with [[Wuchereria bancrofti]], [[Brugia malayi]], or [[Brugia timori]]'' | ||
{{Filariasis dec treatment}} | |||
[[Loa Loa]] | ===[[Loa Loa]]=== | ||
{{loa loa dec treatment}} | |||
===[[Mansonella streptocerca]]=== | |||
* | *6 mg/kg PO qDay x14 days | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
*Day 1: 1 mg/kg orally after meals | *Day 1: 1 mg/kg orally after meals | ||
Latest revision as of 13:14, 3 April 2022
Overview
Diethylcarbamazine (DEC) used globally its anti-filaricidal activity[1]
Administration
- Mechanism of Action: interferes with cyclooxygenase and lipoxygenase pathways, reducing the production of thromboxane, prostacyclin, prostaglandin and leukotrienes
- Dosage Forms: tablets
- Routes of Administration: oral
- Common Trade Names: N/A
Adult Dosing
Lymphatic filariasis
- including lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori
- Day 1: 50mg PO
- Day 2: 50mg TID
- Day 3: 100mg TID
- Days 4-21: 6mg/kg/day divided TID
Loa Loa
- Day 1: 50 mg PO PC
- Day 2: 50 mg PO TID
- Day 3: 100 mg PO TID
- Day 4-21: 9 mg/kg/day PO divided TID
Mansonella streptocerca
- 6 mg/kg PO qDay x14 days
Pediatric Dosing
- Day 1: 1 mg/kg orally after meals
- Day 2: 1 mg/kg orally three times daily
- Day 3: 1-2 mg/kg orally three times daily
- Day 4-14: 6 mg/kg/day orally divided three times daily
Special Populations
Pregnancy Rating
- Do not use diethylcarbamazine in pregnancy.
Lactation risk
Renal Dosing
- Adult:
- Pediatric:
Hepatic Dosing
- Adult:
- Pediatric:
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Anaphylaxis if allergic to Hetrazan
Common
- Fever
- GI distress
Pharmacology
- Half-life: 8hrs
- Metabolism: Partially metabolized to diethylcarbamazine N-oxide.
- Excretion:
Mechanism of Action
Comments
See Also
References
- ↑ Peixoto CA et al. Anti-inflammatory effects of diethylcarbamazine: A review. European Journal of Pharmacology 734 (2014) 35–41