Human papillomavirus: Difference between revisions
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*Abbreviation: HPV | *Abbreviation: HPV | ||
*Most common [[STI]] in US. | *Most common [[STI]] in US. | ||
*Over 200 types | *Over 200 HPV types, with 40 that infect the genital mucosa <ref> Cdc.gov. (2018). Surveillance Manual | HPV | Vaccine Preventable Diseases | CDC. [online] Available at: https://www.cdc.gov/vaccines/pubs/surv-manual/chpt05-hpv.html [Accessed 3 May 2018]. </ref> | ||
*Associated with cervical, vulvar, penile, anal and oropharyngeal cancer. | *Associated with cervical, vulvar, penile, anal and oropharyngeal cancer. | ||
*Vaccine available for adolescents 11 and older, and immunocompromised patients. | *Vaccine available for adolescents 11 and older, and immunocompromised patients. | ||
===HPV Types and Associated Disease Entities=== | |||
{| class="wikitable" style="margin:1em;" | |||
|- | |||
! Disease | |||
! HPV type | |||
|- | |||
| Common [[wart]]s | |||
| 2, 7, 22 | |||
|- | |||
| [[Plantar wart]]s | |||
| 1, 2, 4, 63 | |||
|- | |||
| Verruca plana (flat) | |||
| 3, 10, 28 | |||
|- | |||
| [[Condyloma acuminata]] (anogenital) | |||
| 6, 11, 42, 44 and others | |||
|- | |||
| Anal dysplasia (lesions) | |||
| 6, 16, 18, 31, 53, 58 | |||
|- | |||
| Genital cancers | |||
| | |||
*Highest risk: 16, 18, 31, 45 | |||
*Other high-risk: 33, 35, 39, 51, 52, 56, 58, 59 | |||
*Probably high-risk: 26, 53, 66, 68, 73, 82 | |||
|- | |||
| Epidermodysplasia verruciformis | |||
| more than 15 types | |||
|- | |||
| Focal epithelial hyperplasia (mouth) | |||
| 13, 32 | |||
|- | |||
| Mouth papillomas | |||
| 6, 7, 11, 16, 32 | |||
|- | |||
| Oropharyngeal cancer | |||
| 16 | |||
|- | |||
| Verrucous cyst | |||
| 60 | |||
|- | |||
| Laryngeal papillomatosis | |||
| 6, 11 | |||
|} | |||
==Clinical Features== | ==Clinical Features== | ||
[[File:Dornwarzen.jpg|thumb|Warts on toe.]] | |||
[[File:Largeplanterwart.jpg|thumb|Plantar wart on sole of foot.]] | |||
*Most infections asymptomatic | *Most infections asymptomatic | ||
*Anogenital warts ([[Condyloma acuminata]]) | *Anogenital warts ([[Condyloma acuminata]]) | ||
| Line 21: | Line 69: | ||
==Management== | ==Management== | ||
*Safe-sex counseling | *Safe-sex counseling (HPV-2) | ||
*For genital warts can use: | |||
**Podofilox | |||
**Imiquimod | |||
**Cryotherapy | |||
**Trichloroacetic acid | |||
**Surgical removal | |||
==Disposition== | ==Disposition== | ||
Outpatient follow up | *Outpatient follow up | ||
==See Also== | ==See Also== | ||
| Line 30: | Line 84: | ||
==External Links== | ==External Links== | ||
*http://www.cdc.gov/std/hpv/stdfact-hpv.htm | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 22:28, 18 January 2021
Background
- Abbreviation: HPV
- Most common STI in US.
- Over 200 HPV types, with 40 that infect the genital mucosa [1]
- Associated with cervical, vulvar, penile, anal and oropharyngeal cancer.
- Vaccine available for adolescents 11 and older, and immunocompromised patients.
HPV Types and Associated Disease Entities
| Disease | HPV type |
|---|---|
| Common warts | 2, 7, 22 |
| Plantar warts | 1, 2, 4, 63 |
| Verruca plana (flat) | 3, 10, 28 |
| Condyloma acuminata (anogenital) | 6, 11, 42, 44 and others |
| Anal dysplasia (lesions) | 6, 16, 18, 31, 53, 58 |
| Genital cancers |
|
| Epidermodysplasia verruciformis | more than 15 types |
| Focal epithelial hyperplasia (mouth) | 13, 32 |
| Mouth papillomas | 6, 7, 11, 16, 32 |
| Oropharyngeal cancer | 16 |
| Verrucous cyst | 60 |
| Laryngeal papillomatosis | 6, 11 |
Clinical Features
- Most infections asymptomatic
- Anogenital warts (Condyloma acuminata)
- painless flesh-colored papules or cauliflower-like projections
- Contagious via skin contact
- Cervical cancer
Differential Diagnosis
Sexually transmitted diseases
- Chancroid
- Chlamydia trachomatis
- Granuloma inguinale
- Hepatitis B
- Herpes Simplex Virus-2
- HIV
- Human papillomavirus
- Lymphogranuloma venereum
- Neisseria gonorrhoeae
- Trichomonas
- Syphilis
Evaluation
- Clinical diagnosis
- Pap smear for cervical lesions
Management
- Safe-sex counseling (HPV-2)
- For genital warts can use:
- Podofilox
- Imiquimod
- Cryotherapy
- Trichloroacetic acid
- Surgical removal
Disposition
- Outpatient follow up
See Also
External Links
References
- ↑ Cdc.gov. (2018). Surveillance Manual | HPV | Vaccine Preventable Diseases | CDC. [online] Available at: https://www.cdc.gov/vaccines/pubs/surv-manual/chpt05-hpv.html [Accessed 3 May 2018].