Non-Hodgkin's lymphoma: Difference between revisions
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==Background== | ==Background== | ||
*Can originate in lymphatic system or any organ in the body | *Can originate in lymphatic system or any organ in the body | ||
*Occurs in children | *Occurs in children >5 years old | ||
*Immunosuppression (e.g. [[HIV]], [[crohn's]], chemotherapy) is a risk factor | *Immunosuppression (e.g. [[HIV]], [[crohn's]], chemotherapy) is a risk factor | ||
==Clinical Features== | ==Clinical Features== | ||
*[[Lymphadenopathy]] | *[[Lymphadenopathy]] | ||
*Hepatosplenomegaly | *[[hepatomegaly|Hepatosplenomegaly]] | ||
*"B" symptoms ([[fever]], night sweats, weight loss) | *"B" symptoms ([[fever]], night sweats, weight loss) | ||
*GI: [[GI bleed]], [[intussusception]], [[nausea/vomiting]] | *GI: [[GI bleed]], [[intussusception]], [[nausea/vomiting]] | ||
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==Differential Diagnosis== | ==Differential Diagnosis== | ||
{{Cervical lymphadenopathy DDX}} | {{Cervical lymphadenopathy DDX}} | ||
{{Leuk/lymph DDX}} | {{Leuk/lymph DDX}} | ||
{{Lymphadenitis DDX}} | |||
==Evaluation== | ==Evaluation== | ||
*CBC | *CBC | ||
*BMP, LFTs, uric acid | *BMP, [[LFTs]], uric acid | ||
*[[CXR]] | *[[CXR]] | ||
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==References== | ==References== | ||
<references/> | |||
[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Latest revision as of 22:12, 9 September 2020
Background
- Can originate in lymphatic system or any organ in the body
- Occurs in children >5 years old
- Immunosuppression (e.g. HIV, crohn's, chemotherapy) is a risk factor
Clinical Features
- Lymphadenopathy
- Hepatosplenomegaly
- "B" symptoms (fever, night sweats, weight loss)
- GI: GI bleed, intussusception, nausea/vomiting
- Signs/symptoms of complications:
- Superior vena cava syndrome
- Pleural effusion, pericardial effusion
- Malignant cord compression
- Tumor lysis syndrome (rare in absence of active treatment)
Differential Diagnosis
Cervical Lymphadenopathy
- Hodgkin's lymphoma
- Non-Hodgkin's lymphoma
- Mononucleosis
- Toxoplasmosis
- Branchial cleft lesions
- Cat scratch disease
- Mycobacterial adenitis
Acute Leukemia/Lymphoma
Lymphadenitis
Infectious
- Reactive adenitis
- Bacterial lymphadenitis
- Tuberculous lymphadenitis
- Cellulitis
- Cat-scratch disease
- Parotitis
- Lymphangitis
- Toxoplasmosis
- Tularemia
- Viral disease
- Fungal disease
- Reactive adenitis
Non-Infectious
- Malignancy
- Lymphoma
- Metastatic cancer
- Rheumatologic Disease
- Kawasaki Disease
- Systemic lupus erythematosus
- Sarcoidosis
- Juvenile Idiopathic Arthritis
- Langerhans Cell Histiocytosis
- Cutaneous Lesions:
- Bacillary angiomatosis
- Purpura
- Hematomas
- Angiomas
- Dermatofibromas
- Nevi
- Drug reaction
- Postvaccination
- Sarcoidosis
- Salivary gland diagnoses
Evaluation
Management
See management sections of specific complications:
- Superior vena cava syndrome
- Pleural effusion, pericardial effusion
- Malignant cord compression
- Tumor lysis syndrome
- Neutropenic fever
- Nausea/vomiting
- GI bleeding, intussusception