Hodgkin's lymphoma: Difference between revisions
ClaireLewis (talk | contribs) |
|||
| (3 intermediate revisions by 2 users not shown) | |||
| Line 6: | Line 6: | ||
*Bimodal distribution: young adulthood and older aged | *Bimodal distribution: young adulthood and older aged | ||
*Most common malignancy in ages 15-19 years | *Most common malignancy in ages 15-19 years | ||
*Survival | *Survival >90% in low-risk patients | ||
==Clinical Features== | ==Clinical Features== | ||
| Line 14: | Line 14: | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
{{Cervical lymphadenopathy DDX}} | {{Cervical lymphadenopathy DDX}} | ||
{{Leuk/lymph DDX}} | {{Leuk/lymph DDX}} | ||
{{Lymphadenitis DDX}} | |||
==Evaluation== | ==Evaluation== | ||
| Line 38: | Line 38: | ||
==References== | ==References== | ||
<references/> | |||
[[Category:Heme/Onc]] | [[Category:Heme/Onc]] | ||
Latest revision as of 21:44, 9 September 2020
Background
- Spreads from source lymph node to adjacent nodes
- About half of cases related to Epstein-Barr virus[1]
- HIV is also a risk factor
- More common in males
- Bimodal distribution: young adulthood and older aged
- Most common malignancy in ages 15-19 years
- Survival >90% in low-risk patients
Clinical Features
- Painless, firm, lymph node (usually cervical or supraclavicular)
- "B" symptoms: fever, night sweats, weight loss
Differential Diagnosis
Cervical Lymphadenopathy
- Hodgkin's lymphoma
- Non-Hodgkin's lymphoma
- Mononucleosis
- Toxoplasmosis
- Branchial cleft lesions
- Cat scratch disease
- Mycobacterial adenitis
Acute Leukemia/Lymphoma
Lymphadenitis
Infectious
- Reactive adenitis
- Bacterial lymphadenitis
- Tuberculous lymphadenitis
- Cellulitis
- Cat-scratch disease
- Parotitis
- Lymphangitis
- Toxoplasmosis
- Tularemia
- Viral disease
- Fungal disease
- Reactive adenitis
Non-Infectious
- Malignancy
- Lymphoma
- Metastatic cancer
- Rheumatologic Disease
- Kawasaki Disease
- Systemic lupus erythematosus
- Sarcoidosis
- Juvenile Idiopathic Arthritis
- Langerhans Cell Histiocytosis
- Cutaneous Lesions:
- Bacillary angiomatosis
- Purpura
- Hematomas
- Angiomas
- Dermatofibromas
- Nevi
- Drug reaction
- Postvaccination
- Sarcoidosis
- Salivary gland diagnoses
Evaluation
- CXR
- CT neck/chest/abdomen/pelvis
- Lymph node biopsy
- Reed-Sternberg cells next to normal lymphocytes
Management
- Manage acute complications
- Superior vena cava syndrome
- Upper airway compression
- Do NOT give steroids (citation/rationale?)
- Tumor lysis syndrome
- Neutropenic fever
- Chemo-induced nausea/vomiting
See Also
References
- ↑ World Cancer Report 2014. World Health Organization. 2014. pp. Chapter 2.4