Template:Acute hepatitis causes: Difference between revisions
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===Causes of [[acute hepatitis]]=== | ===Causes of [[acute hepatitis]]=== | ||
*[[Acetaminophen toxicity]] (most common cause of acute liver failure in the US<ref>Ostapowicz G, Fontana RJ, Schiodt FV, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002 Dec 17; 137(12): 947-54.</ref>) | |||
*[[Viral hepatitis]] | *[[Viral hepatitis]] | ||
**[[Hepatitis A]] | **[[Hepatitis A]] | ||
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**[[Hepatitis E]] | **[[Hepatitis E]] | ||
*[[Acute alcoholic hepatitis]] | *[[Acute alcoholic hepatitis]] | ||
*[[Mushroom toxicity]] | *[[Mushroom toxicity]] | ||
**[[Crotinarius mushrooms]] | **[[Crotinarius mushrooms]] | ||
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**[[Amanita mushrooms]] | **[[Amanita mushrooms]] | ||
*[[Ischemic hepatitis]] | *[[Ischemic hepatitis]] | ||
===Causes=== | |||
*[[Alcoholic hepatitis]] and other Alcohol-related Liver Disease | |||
====Drug or Toxin Related Liver Disease==== | |||
*Liver damage from drugs or toxins may be cytotoxic from the primary drug or its metabolites, or may be caused by veno-occlusive disease or hypersensitivity disease<ref>Oyama, LC: Disorders of the Liver and Biliary Tractin Marx JA, Hockberger RS, Walls RM, et al (eds): Rosen’s Emergency Medicine: Concepts and Clinical Practice, ed 8. St. Louis, Mosby, Inc., 2014, (Ch) 107: p 1186-1204</ref> | |||
*Common Drugs and Toxins | |||
**[[Acetaminophen]] | |||
**[[Amiodarone]] | |||
**[[Amphotericin]] | |||
**Anabolic steroids | |||
**[[Azathioprine]] | |||
**[[Carbamazepine]] | |||
**[[Chlorpromazine]] | |||
**Cisplatin | |||
**Contraceptives | |||
**[[Cyclophosphamide]] | |||
**[[Erythromycin]] | |||
**Gold salts | |||
**[[Haloperidol]] | |||
**[[Isoniazid]] | |||
**[[Ketoconazole]] | |||
**Lovastatin | |||
**[[Methotrexate]] | |||
**Methoxyflurane | |||
**Methyldopa | |||
**[[Phenobarbital]] | |||
**[[Phenytoin]] | |||
**[[Quinidine]] | |||
**[[Salicylates]] | |||
**[[Tetracycline]] | |||
**[[Valproic acid]] | |||
**[[Verapamil]] | |||
===Other Rare Causes of Acute Liver Failure=== | |||
*'''[[Wilson's disease]]''': unexplained elevations in LFTs, neuro-psychiatric symptoms, Kayser-Fleischer rings on eye exam | |||
*'''[[Autoimmune hepatitis]]''': more common in women, liver disease without explanation, may have family history of other autoimmune disorders | |||
*'''[[Hemochromatosis]]''': family history of liver disease and cardiac disease | |||
*'''[[Budd-Chiari]]''': history of hypercoagulable disorder, abdominal pain, and ascites | |||
*'''Infections''': [[HSV]], [[Epstein-Barr virus]], [[varicella zoster virus]], [[toxoplasmosis]] | |||
Revision as of 18:27, 4 June 2020
Causes of acute hepatitis
- Acetaminophen toxicity (most common cause of acute liver failure in the US[1])
- Viral hepatitis
- Acute alcoholic hepatitis
Causes
- Alcoholic hepatitis and other Alcohol-related Liver Disease
Drug or Toxin Related Liver Disease
- Liver damage from drugs or toxins may be cytotoxic from the primary drug or its metabolites, or may be caused by veno-occlusive disease or hypersensitivity disease[2]
- Common Drugs and Toxins
- Acetaminophen
- Amiodarone
- Amphotericin
- Anabolic steroids
- Azathioprine
- Carbamazepine
- Chlorpromazine
- Cisplatin
- Contraceptives
- Cyclophosphamide
- Erythromycin
- Gold salts
- Haloperidol
- Isoniazid
- Ketoconazole
- Lovastatin
- Methotrexate
- Methoxyflurane
- Methyldopa
- Phenobarbital
- Phenytoin
- Quinidine
- Salicylates
- Tetracycline
- Valproic acid
- Verapamil
Other Rare Causes of Acute Liver Failure
- Wilson's disease: unexplained elevations in LFTs, neuro-psychiatric symptoms, Kayser-Fleischer rings on eye exam
- Autoimmune hepatitis: more common in women, liver disease without explanation, may have family history of other autoimmune disorders
- Hemochromatosis: family history of liver disease and cardiac disease
- Budd-Chiari: history of hypercoagulable disorder, abdominal pain, and ascites
- Infections: HSV, Epstein-Barr virus, varicella zoster virus, toxoplasmosis
- ↑ Ostapowicz G, Fontana RJ, Schiodt FV, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002 Dec 17; 137(12): 947-54.
- ↑ Oyama, LC: Disorders of the Liver and Biliary Tractin Marx JA, Hockberger RS, Walls RM, et al (eds): Rosen’s Emergency Medicine: Concepts and Clinical Practice, ed 8. St. Louis, Mosby, Inc., 2014, (Ch) 107: p 1186-1204