Dexamethasone: Difference between revisions
| Line 41: | Line 41: | ||
==Pharmacology== | ==Pharmacology== | ||
*Half-life: | *Half-life: | ||
*Metabolism: | ** Adults: Oral 4 ± 0.9 hours, IV 1 - 5 hours | ||
*Excretion: | *Metabolism: Hepatic | ||
*Mechanism of Action: | *Excretion: Urine ~10% | ||
*Mechanism of Action: surpasses neutrophil migration, decreases production of inflammatory mediators, reverses increased capillary permeability, suppresses normal immune response | |||
==See Also== | ==See Also== | ||
Revision as of 17:55, 2 April 2019
General
- Type: Corticosteroid
- Dosage Forms: PO; IM; IV
- Common Trade Names:
Adult Dosing
Anaphylaxis
- 10mg IV or PO
Pediatric Dosing
Anaphylaxis
- 0.6mg/kg
Asthma Exacerbation
- 0.6mg/kg once PO
Post-operative Airway Edema
- 0.5 mg/kg PO q6hrs x1-2 days
Special Populations
- Pregnancy Rating: C
- Lactation: Single doses are considered compatible however corticosteroids are present in breast milk and further discussion should be had with mother due to potential serious adverse reactions in breastfed infant.
- Renal Dosing
- Adult
- Not defined
- Pediatric
- Not defined
- Adult
- Hepatic Dosing
- Adult
- Not defined
- Pediatric
- Not defined
- Adult
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
Common
Pharmacology
- Half-life:
- Adults: Oral 4 ± 0.9 hours, IV 1 - 5 hours
- Metabolism: Hepatic
- Excretion: Urine ~10%
- Mechanism of Action: surpasses neutrophil migration, decreases production of inflammatory mediators, reverses increased capillary permeability, suppresses normal immune response