Fresh frozen plasma

From WikEM
(Redirected from Fresh Frozen Plasma)
Jump to: navigation, search


Adult Dosing

  • Transfuse at least 15 mL/kg at a time (4 units in 70-kg adult)

Pediatric Dosing

Special Populations

  • Pregnancy Rating:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric


  • Rapid reversal of warfarin over-anticoagulation
  • Bleeding and multiple coagulation defects
  • Correction of coagulation defects for which no specific factor is available
  • Transfusion of more than one blood volume with evidence of active bleeding + coagulopathy


  • Allergy to class/drug

Adverse Reactions




  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:


  • Contains all coagulation factors and fibrinogen
    • 40 mL/kg raises any factor by 100% (each unit is ~200mL)
  • May cause fluid overload
  • ABO compatibilty a must but crossmatch before transfusing not
  • INR of FFP is ~1.6; therefore transfusing for INR <1.7 is not advised[1]
  • Retains active coagulation factors for up to 5 days after being thawed

See Also


  1. Holland LL and Brooks JP. Toward rational fresh frozen plasma transfusion: The effect of plasma transfusion on coagulation test results. Am J Clin Pathol. 2006;126(1):133-9.