Tramadol: Difference between revisions
(Created page with "==General== *Type: opioid *Dosage Forms: PO *Common Trade Names: Ultram, Ryzolt ==Adult Dosing== ===General=== Pain: *50-100 mg PO q4-6h PRN, Chronic severe pain: *100-30...") |
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*Mechanism of Action:exact mechanism unknown, binds to mu opioid receptors and weakly inhibits NE/Serotonin reuptake | *Mechanism of Action:exact mechanism unknown, binds to mu opioid receptors and weakly inhibits NE/Serotonin reuptake | ||
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Revision as of 20:53, 20 October 2015
General
- Type: opioid
- Dosage Forms: PO
- Common Trade Names: Ultram, Ryzolt
Adult Dosing
General
Pain:
- 50-100 mg PO q4-6h PRN,
Chronic severe pain:
- 100-300 mg ER PO QDAY
Pediatric Dosing
Not Currently recommended
Special Populations
- Pregnancy Rating: C
- Lactation Risk Categories: Probably safe
- Renal Dosing
- Adult: CrCL < 30: given q12h, max 200 mg/day
- Pediatric: none
- Hepatic Dosing
- Adult: cirrhosis: 50 mg q12h, max 100 mg/day
- Pediatric: not defined
Contraindications
- Allergy to class/drug
- asthma, acute
- respiratory depression
- severe hepatic impairment
- severe renal impairment
- acute alcohol intoxication
Adverse Reactions
Serious
- Respiratory Depression
- suicidal ideation
- Seizures
- anaphylaxis
- serotonin syndrome
- steven johnson syndrome
Common
- Nausea
- Rash
- Headache
- Fatigue
- xerostomia
- constipation
- Tremor
- insomnia
Pharmacology
- Half-life: 6.3 - 7.9 hour
- Metabolism: Liver
- Excretion: urine
- Mechanism of Action:exact mechanism unknown, binds to mu opioid receptors and weakly inhibits NE/Serotonin reuptake