Pregabalin

Administration

• Type: GABA analog, analgesic
• Dosage Forms:
• Routes of Administration: oral
• Common Trade Names: Lyrica

Adult Dosing

• 50-200mg PO TID

Pediatric Dosing

Safety/efficacy not established

Special Populations

• Pregnancy Rating: C (though fetal risk has been demonstrated)
• Lactation risk: Infant risk has been demonstrated
• Renal dosing: reduce dose per manufacturer/FDA guidelines
• Hepatic dosing:

Contraindications

• Allergy to class/drug

Adverse Reactions

Serious

• Angioedema, hypersensitivity reaction
• Jaundice
• Elevated creatine kinase level
• Suicidal thoughts

Common

• Constipation, xerostomia, weight gain
• Peripheral edema
• Dizziness, ataxia, somnolence, blurred vision, headache
• Nasopharyngitis
• Disturbance in thinking, euphoria

Pharmacology

• Half-life: 6.3h
• Metabolism:
• Excretion: Mostly renal

Mechanism of Action

• GABA-analog, exact mechanism of analgesic effect poorly understood