Multidose activated charcoal

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Background

  • Method of enhanced elimination that uses multiple doses of activated charcoal
  • No evidence to suggest that MDAC decreases morbidity or mortality
    • Some evidence shows that MDAC increases the elimination of certain drugs (further explained below)

Dosing

  • 12.5 g/hr in divided doses (eg. 50g Q4hr)

Contraindications

  • Same as with single dose activated charcoal (SDAC)
  • Intestinal obstruction (absolute)
  • Decreased gut motility (relative)

Indications

  • Mnemonic: These People Drink Charcoal Quickly
    • Theophylline
    • Phenobarbital
    • Dapsone
    • Carbamazepine
    • Quinine

Mechanism of Action

  1. Stops enterohepatic circulation
  2. Increases passive diffusion and acts as a sink for the xenobiotics
  3. Binds drugs in extended release formulations

See Also

Activated Charcoal

Source

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