INH toxicity
Background
- Causes low Pyridoxine B6 stores
- B6 used to make gaba- an inhibitory neurotransmitter
- Also inhibits lactate to pyruvate conversion
Treatment
- Adults - 1 g of pyridoxine for each gram of INH ingested, to a maximum of 5 g
- Children - 1gm/kg regardless of age [1]
Rate - slow IV infusion at approximately 0.5 g/min until the seizures stop or the maximum dose is reached. Remainder of dose infused over 4 to 6 hours.
Source
6/06 MISTRY & Goldfrank's Toxicologic Emergencies
- ↑ Minns, A. et al. Isoniazid-Induced Status Epilepticus in a Pediatric Patient After Inadequate Pyridoxine Therapy. Pediatric Emergency Care. 2010:26(5)380-381