INH toxicity

Background

• Causes low Pyridoxine B6 stores
• B6 used to make gaba- an inhibitory neurotransmitter
• Also inhibits lactate to pyruvate conversion

Treatment

• Adults - 1 g of pyridoxine for each gram of INH ingested, to a maximum of 5 g
• Children - 70 mg/kg

Rate - slow IV infusion at approximately 0.5 g/min until the seizures stop or the maximum dose is reached. Remainder of dose infused over 4 to 6 hours.

Source

6/06 MISTRY & Goldfrank's Toxicologic Emergencies