INH toxicity: Difference between revisions
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==Treatment== | ==Treatment== | ||
* | *Adults - 1 g of pyridoxine for each gram of INH ingested, to a maximum of 5 g | ||
*Children - 70 mg/kg | |||
Rate - slow IV infusion at approximately 0.5 g/min until the seizures stop or the maximum dose is reached. Remainder of dose infused over 4 to 6 hours. | |||
==Source== | ==Source== | ||
6/06 MISTRY | 6/06 MISTRY & Goldfrank's Toxicologic Emergencies | ||
[[Category:Tox]] | [[Category:Tox]] | ||
Revision as of 17:36, 5 December 2012
Background
- Causes low Pyridoxine B6 stores
- B6 used to make gaba- an inhibitory neurotransmitter
- Also inhibits lactate to pyruvate conversion
Treatment
- Adults - 1 g of pyridoxine for each gram of INH ingested, to a maximum of 5 g
- Children - 70 mg/kg
Rate - slow IV infusion at approximately 0.5 g/min until the seizures stop or the maximum dose is reached. Remainder of dose infused over 4 to 6 hours.
Source
6/06 MISTRY & Goldfrank's Toxicologic Emergencies