Fenoldopam
Administration
- Type: Antihypertensive, Dopamine agonist
- Dosage Forms: 10mg/mL (1 mL), 20mg/2 mL (2 mL)
- Routes of Administration: Intravenous
- Common Trade Names: Corlopam
Adult Dosing
- Severe hypertension: Initial 0.01 to 0.3 msg/kg/minute, increase incrementally 0.05 to 0.1 msg/kg/minute q 15 minute until target blood pressure is reached (maximum dose recorded in the study was 1.6 mcg/kg/minute), limit for up to 48-hour use.
Pediatric Dosing
- Severe hypertension: Initial 0.2 mcg/kg/minute; increase incrementally 0.3 to 0.5 mcg/kg/minute q 20 to 30 minutes (maximum 0.8 mcg/kg/minute), limit for 4-hour use
Special Populations
- Pregnancy Rating: B
- Lactation risk: Not defined
Renal Dosing
- Adult: Not defined
- Pediatric: Not defined
Hepatic Dosing
- Adult: Not defined
- Pediatric: Not defined
Contraindications
- Allergy to class/drug
- Caution if:
- hypersens to sulfites
- asthma
- glaucoma
- intraocular HTN
- acute stroke
- ICP incr
- cardiac dz
- arrhythmias
- hypokalemia
- active bleeding
- portal HTN
Adverse Reactions
Serious
- hypotension, severe
- tachycardia
- CHF
- MI
- angina
- hypokalemia
- leukocytosis
Common
- headache
- flusing
- hypotension
- ST-T wave changes
- nausea/vomiting
- injection site rxn
- dizziness
- back pain
- abdominal pain
- diaphoresis
- tachycardia
- constipation
- diarrhea
- nasal congestion
- anxiety
- IOP elevation
Pharmacology
- Half-life: 5 min
- Metabolism: Liver extensively; CYP450
- Excretion: urine 90%, feces 10%
Mechanism of Action
- stimulates dopamine D1-like and alpha-2 adrenergic receptors