Anticonvulsants: Difference between revisions

Latest revision as of 20:44, 19 October 2022

Drug	Dose	Infusion Rate (Minutes)	Age	Comments/Cautions
Levetiracetam	60 mg/kg/dose IV/IO MAX: 4500 mg/dose	≥5	Any	Most commonly used agent
Fosphenytoin	20 mg phenytoin equivalent (PE)/kg/dose IV/IO/IM MAX: 1000 PE/dose	≥10	Any	Choose alternate drug if on phenytoin at home; may decrease BP/HR; not for toxin-induced seizures
Valproic acid	40 mg/kg/dose IV/IO MAX: 3000 mg/dose	≥10	≥2 years	Caution in patients with liver dysfunction, mitochondrial disease, urea disorder, thrombocytopenia, or unexplained developmental delay
Phenytoin	20 mg/kg/dose IV/IO MAX: 1000 mg/dose	≥20	Any	Choose alternate drug if on phenytoin at home; may decrease BP/HR; not for toxin-induced seizures
Phenobarbital	20 mg/kg/dose IV/IO MAX: 1000 mg/dose	≥20	<6 months	First line for most neonatal seizures. Respiratory depression, especially in combination with benzodiazepines

@@ Line 19: / Line 19: @@
 *[[Zonisamide]]
-===Pediatric [[Anticonvulsants]] Table ===
+{{Pediatric anticonvulsants}}
-{| class="wikitable"
-! Drug !! Dose !! Infusion Rate (Minutes)!! Age !! Comments/Cautions
-|-
-| [[Levetiracetam]] ||
-*60 mg/kg/dose IV/IO
-*MAX: 3000 mg/dose
-|| ≥5 || Any || Most commonly used agent
-|-
-| [[Fosphenytoin]] ||
-*20 mg phenytoin equivalent (PE)/kg/dose IV/IO/IM
-*MAX: 1000 PE/dose
-|| ≥10 || Any || Choose alternate drug if on phenytoin at home; may decrease BP/HR
-|-
-| [[Valproic acid]] ||
-*40 mg/kg/dose IV/IO
-*MAX: 3000 mg/dose
-|| ≥10 || ≥2 years || Caution in patients with liver dysfunction, mitochondrial disease, urea disorder, thrombocytopenia, or unexplained developmental delay
-|-
-| [[Phenytoin]] ||
-*20 mg/kg/dose IV/IO
-*MAX: 1000 mg/dose
-|| ≥20 || Any || Choose alternate drug if on phenytoin at home; may decrease BP/HR
-|-
-| [[Phenobarbital]] ||
-*20 mg/kg/dose IV/IO
-*MAX: 1000 mg/dose
-|| ≥20 || <6 months || Respiratory depression, especially in combination with benzos
-|}
 ==See Also==