Acute myeloid leukemia: Difference between revisions
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==Background== | ==Background== | ||
* | *AKA Acute myelogenous leukemia or non-lymphocytic leukemia | ||
*Most common acute leukemia in adults (around 80% of cases) | *Most common acute leukemia in adults (around 80% of cases) | ||
* | *65 yo median age of diagnosis, Male:Female 5:3 | ||
* | *Characterized by clonal proliferation of myeloid precursors(blast cells >20% in the periphery) | ||
==Clinical Features== | ==Clinical Features== | ||
*Presents with anemia, neutropenia, thrombocytopenia, | *Presents with anemia, neutropenia, thrombocytopenia, | ||
* | *Weakness, easy fatigability, infections, gingival bleeding/enlargement, ecchymoses, epistaxis, menorrhagia | ||
==Differential Diagnosis== | ==Differential Diagnosis== | ||
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*If febrile, complete cultures and broad spectrum antibiotics | *If febrile, complete cultures and broad spectrum antibiotics | ||
*Manage Complications | *Manage Complications | ||
** | **See [[DIC]] | ||
** | **See [[Leukostasis]] | ||
** | **See [[Hyperviscosity syndrome]] | ||
** | **See [[Tumor Lysis Syndrome]] | ||
** | **See [[Retinoic acid syndrome]] | ||
==See Also== | ==See Also== | ||
Revision as of 22:20, 18 January 2017
Background
- AKA Acute myelogenous leukemia or non-lymphocytic leukemia
- Most common acute leukemia in adults (around 80% of cases)
- 65 yo median age of diagnosis, Male:Female 5:3
- Characterized by clonal proliferation of myeloid precursors(blast cells >20% in the periphery)
Clinical Features
- Presents with anemia, neutropenia, thrombocytopenia,
- Weakness, easy fatigability, infections, gingival bleeding/enlargement, ecchymoses, epistaxis, menorrhagia
Differential Diagnosis
Acute Leukemia/Lymphoma
Evaluation
- CXR
- CBC with peripheral smear
- Chem7, ca, mg, phos, Uric Acid, UA, LDH (to check for Tumor Lysis)
- LFTs, Coags, FDP, D-Dimer, Haptoglobin, Fibrinogen (to check for DIC)
- Get extra purple top for flow cytometry, especially before transfusion
Treatment
- Aggressive IV hydration
- If febrile, complete cultures and broad spectrum antibiotics
- Manage Complications
- See DIC
- See Leukostasis
- See Hyperviscosity syndrome
- See Tumor Lysis Syndrome
- See Retinoic acid syndrome