Warfarin-induced skin necrosis

WarfarinNecrosis.png

Background

  • Differing half-lives of Vitamin-K dependent coagulation factors leads to relative protein C deficiency initially→ hypercoagulability
  • Onset usually in first week of starting warfarin

Clinical Features

  • Painful, red lesions over extremities, trunk, penis
  • Start with erythematous macule→ edema→ central purpuric zones → necrosis

Differential Diagnosis

Necrotizing rashes

Evaluation

  • Clinical diagnosis

Management

Disposition

See Also

External Links

References