Trientine

Administration

  • Type: Antidote
  • Dosage Forms: Capsule 250mg
  • Routes of Administration: Oral
  • Common Trade Names: Syprine

Adult Dosing

Wilson's disease

  • 750-1250 mg/day PO divided BID-QID
    • Max: 2000 mg/day

Pediatric Dosing

Wilson's disease

  • < 13 yo
    • 20 mg/kg/day PO divided BID-TID
  • 13 yo +
    • 750-1250 mg/day divided BID-QID

Special Populations

Pregnancy Rating

  • Clinical caution advised during pregnancy

Lactation risk

  • Caution advised while breastfeeding

Renal Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Hepatic Dosing

  • Adult: Not defined
  • Pediatric: Not defined

Contraindications

Adverse Reactions

Serious

  • May occur, but none have been reported

Common

Lupus erythematosus

  • Contact dermatitis

Pharmacology

  • Half-life: Unknown
  • Metabolism: Unknown
  • Excretion: Urine

Mechanism of Action

  • Chelates copper for excretion from the body

Comments

See Also

References

Authors:

Jonathan Warren