Triazolam

Administration

  • Type: Benzodiazepine
  • Dosage Forms:
  • Routes of Administration: oral
  • Common Trade Names: Halcion

Adult Dosing

  • 0.25-0.5mg PO qHS

Pediatric Dosing

Safety/efficacy not established

Special Populations

Contraindications

  • Allergy to class/drug
  • Concomitant use of potent CYP 3A inhibitors (e.g. itraconazole, ketoconazole, nefazodone, protease-inhibitors)
  • Pregnancy

Adverse Reactions

Serious

  • Respiratory depression, apnea
  • Liver failure, cholestatic jaundice syndrome
  • Amnesia, abnormal behavior, worsening depression, suicidal thoughts
  • Dystonia
  • Paradoxical excitability
  • Drug dependence, withdrawal

Common

  • Somnolence
  • Dizziness, lightheadedness
  • Nervousness
  • Headache

Pharmacology

  • Half-life: 1.5-5h
  • Metabolism: Hepatic, via CYP3A
  • Excretion: Renal

Mechanism of Action

  • Triazolobenzodiazepine, GABA-receptor agonist

Comments

See Also

References

Authors:

Claire