Transient global amnesia
- Paroxysmal, transient retrograde amnesia lasting several hours
- Most common in female 40-60yo
- Retrograde amnesia
- Unaware of their memory loss
- Normal attention and social skills
- Periods of time typically less than 24 hrs, but typically lasts 4-6 hrs
- No localizing symptoms
- If localizing symptoms, consider alternative diagnosis
- Hyperosmotic Coma
- Drug toxicity
- Lithium, phenytoin, carbamazepine
- Complicated migraine
- Demyelinating disease (MS)
- Conversion disorder
Depending on presentation, consider CVA workup
- Bedside glucose
- Bedside hemoglobin (polycythemia)
- ECG (esp A-fib)
- Head CT
- Primarily used to exclude intracranial bleeding, abscess, tumor, other stroke mimics
- Also consider:
- Rule out CVA (clinically or with further workup)
- Neurology referral
- Once diagnosed, no specific treatment needed
- Discharge home with neurology follow up
- Consider admission for equivocal cases
- Full recovery with amnesia of event
- Annual recurrence rate was 4.7%
- Lin KH, et al. Migraine is associated with a higher risk of transient global amnesia: a nationwide cohort study. Eur J Neurol. 2014; 21(5):718-24.
- Zeman AZ, et al..Transient global amnesia. Br J Hosp Med. 1997; 58:257-60.
- Owen D, et al. Classical diseases revisited: transient global amnesia. Postgrad Med J. 2007; 83(978):236–239.
- Hinge HH, et al. The prognosis of transient global amnesia. Results of a multicenter study. Arch Neurol. 1986; 43(7):673-6.