Terbinafine

Administration

  • Type: Antifungal
  • Dosage Forms:
  • Routes of Administration: Oral, topical
  • Common Trade Names:

Adult Dosing

  • 250-500mg PO 1-2 times per day
  • Apply topically 1-2 times per day

Pediatric Dosing

  • >12yo, topical: apply 1-2 times per day
  • >4yo, oral
    • <25kg: 125mg PO daily
    • 25-35kg: 187.5mg PO daily
    • >25kg: 250mg PO daily

Special Populations

Contraindications

  • Allergy to class/drug
  • Chronic or active liver disease

Adverse Reactions

Serious

  • SJS/TEN
  • Acute generalized exanthematous pustulosis
  • Systemic or cutaneous lupus
  • Neutropenia
  • Liver failure
  • Hearing loss

Common

  • Nausea, vomiting, diarrhea, indigestion
  • Rash
  • Elevated LFTs
  • Headache
  • Cough, fever, URI symptoms

Pharmacology

  • Half-life: 22-26h
  • Metabolism: Hepatic CYP2C9, CYP1A2, CYP3A4, CYP2C8 and CYP2C19
  • Excretion: Mostly renal

Mechanism of Action

  • Inhibits ergosterol in fungal cell membrane

Comments

See Also

References

Authors:

Claire