Template:PCP pneumonia antibiotics
Mild Disease
- TMP/SMX 2 DS tablets PO q8hrs OR
- High incidence of allergy in HIV
- Dapsone 100mg PO once daily + TMP 5mg/kg PO q8hrs OR
- caution: dapsone can cause methemoglobinemia
- Atavaquone 750mg PO q12hrs OR
- Primaquine 30mg PO q24hrs + Clindamycin 450mg PO q8hrs
Severe Disease
- TMP/SMX 5mg/kg IV q8hrs x 21 days OR
- Pentamidine 4mg/kg IV daily over 60 min OR
- Watch for side effects of hypoglycemia and hypotension
- Primaquine 30mg PO once daily + Clindamycin 900mg IV q8hrs
Prophylaxis
- TMP/SMX 1 DS tablet daily, but one single strength tablet daily or one double-strength three times weekly is acceptable.[1]
Pediatric Treatment
- TMP/SMX 5mg/kg (TMP) IV/PO q6-8hrs x 21 days
- Pentamidine 4mg/kg IV daily x 21 days if TMP/SMX intolerant
- Dapsone 2mg/kg/day PO (max 100mg) + TMP 15mg/kg/day PO divided TID for mild disease
Pediatric Prophylaxis
- TMP/SMX 5mg/kg/day (TMP) PO divided BID 3 days/week (first line)
- Dapsone 2mg/kg/day PO daily (max 100mg) or Atovaquone as alternatives
- ↑ CDC Guidelines for Prophylaxis Against Pneumocystis carinii Pneumonia for Children Infected with Human Immunodeficiency Virus http://www.cdc.gov/mmwr/preview/mmwrhtml/00001957.htm