Template:Erysipelas antibiotics
Coverage for S. pyogenes
- Penicillin G 300K U/d IM for <30 kg, 600K to 1 million U/d IM for >30 kg (first line therapy[1]) OR
- Clindamycin 450mg (5mg/kg) PO q8hrs x 10 days (if PCN allergic) OR
- Cephalexin 500mg (6.25mg/kg) PO q6hrs x 10 days OR
- Ceftriaxone 1g (50mg/kg) IV once daily x 10 days OR
- Levofloxacin 500mg PO/IV daily x 10 days OR
- Amoxicillin/Clavulanate 500mg PO BID x 10 days (generally reserved for failure of first line therapy)
Bullous Erysipela or MRSA suspected: trimethoprim-sulfamethoxazole, clindamycin, doxycycline, or minocycline
Pediatric
- Penicillin G <30kg: 300,000 U/day IM; >30kg: 600,000-1 million U/day IM OR
- Cephalexin 25-50mg/kg/day PO divided q6-8h x 10 days (max 500mg/dose) OR
- Clindamycin 30mg/kg/day PO divided TID x 10 days (max 1.8g/day) OR
- Ceftriaxone 50mg/kg IV daily (max 2g) x 10 days
- ↑ Linke M, Booken N. Risk factors associated with a reduced response in the treatment of erysipelas. J Dtsch Dermatol Ges. 2015 Mar;13(3):217-25.