Interactive Anion Gap calculator with albumin correction. Requires the calculator gadget.
Usage: {{Anion Gap Calculator}}
Anion Gap
Anion Gap Calculator
| Parameter
|
Value
|
| Sodium (Na⁺) mEq/L
|
|
| Chloride (Cl⁻) mEq/L
|
|
| Bicarbonate (HCO₃⁻) mEq/L
|
|
| Albumin (g/dL) — optional, for correction
|
|
| Results
|
| Anion Gap
|
mEq/L
|
| Corrected AG (for albumin)
|
mEq/L
|
| Delta-Delta Ratio (ΔAG / ΔHCO₃)
|
|
| Interpretation
|
| AG <12
|
Normal anion gap — Consider non-AG metabolic acidosis (HARDUPS mnemonic).
|
| AG ≥12
|
Elevated anion gap — Consider MUDPILES: Methanol, Uremia, DKA, Propylene glycol, Isoniazid/Iron, Lactic acidosis, Ethylene glycol, Salicylates.
|
| Delta-Delta Ratio
|
| <1
|
Concurrent non-AG metabolic acidosis (mixed).
|
| 1–2
|
Pure anion gap metabolic acidosis.
|
| >2
|
Concurrent metabolic alkalosis (or pre-existing elevated HCO₃).
|
| References
|
- Kraut JA, Madias NE. Serum anion gap: its uses and limitations in clinical medicine. Clin J Am Soc Nephrol. 2007;2:162-174. PMID 17699401.
- Fenves AZ et al. Increased anion gap metabolic acidosis as a result of 5-oxoproline (pyroglutamic acid). Proc (Bayl Univ Med Cent). 2006;19:364-367.
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