Tamsulosin

Administration

  • Type: α-blocker
  • Dosage Forms:
  • Routes of Administration: oral
  • Common Trade Names: Flomax

Adult Dosing

  • 0.4mg PO once daily or nightly

Urolithiasis

  • 0.4mg PO QHS until stone expulsion

Pediatric Dosing

Safety/efficacy not established

Special Populations

Renal Dosing

  • Adult: No adjustment for CrCl >10

Hepatic Dosing

  • Adult: No adjustment

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Retinal detachment
  • Priapism

Common

  • Headache, dizziness, insomnia, somnolence
  • Abnormal ejaculation
  • Rhinitis
  • Back pain

Pharmacology

  • Half-life: 9-15h
  • Metabolism: CYP3A4 and CYP2D6
  • Excretion: Mostly renal

Mechanism of Action

  • α-1A antagonist→ smooth muscle relaxation in bladder neck, prostate, urethra→ increased urine flow rate

Comments

See Also

References