Sulfadiazine

Administration

  • Type: Antibiotic
  • Dosage Forms: Tablet, 500mg
  • Routes of Administration: Oral
  • Common Trade Names:

Adult Dosing

  • 2-4g PO daily in 1-4 doses

Pediatric Dosing

  • >2mo: 75-150 mg/kg PO daily in 1-4 doses

Special Populations

Contraindications

  • Allergy to class/drug
  • Infants <2mo (except to treat congenital toxoplasmosis)
  • Pregnant women at term
  • Breastfeeding

Adverse Reactions

Serious

  • SJS/TEN
  • Agranulocytosis, hemolytic anemia, leukopenia, thrombocytopenia, aplastic anemia
  • Crystalluria
  • Allergic Myocarditis

Common

  • Rash
  • Nausea/vomiting, diarrhea, abdominal pain
  • Tinnitus
  • Headache, Depression, Insomnia

Pharmacology

  • Half-life: 7-16.8h
  • Metabolism: Hepatic
  • Excretion: Mostly renal

Mechanism of Action

  • Inhibits bacterial synthesis of folic acid

Comments

See Also

References