- An average of 5000 native venomous snakebites are reported to US poison centers annually
- In the United States, snake bites can be organized into Crotaline (Pit Vipers) and Elapidae (Coral Snakes)
- Crotalidae family also includes rattlesnakes, Sistrurus and Agkistrodon species (water moccasins and copperheads).
- Risk Factors: "The 'T's" Testosterone, Tequila, Tshirt, Tattoos, Toothless, Teasing, Trailer park, Truck
- Snake venom is a mixture of proteins, peptides, lipids, and metal ions.
- Many bites can be "dry bites" where no venom is released, about ~1/4
- Local injury - punctures marks from fangs not always visible; erythema, and edema
- Ooze at fang mark reliable sign of envenomation
- Hymenoptera stings (bees, wasps, ants)
- Mammalian bites
- Marine toxins and envenomations
- Toxins (ciguatera, neurotoxic shellfish poisoning, paralytic shellfish poisoning, scombroid, tetrodotoxin
- Stingers (stingray injury)
- Venomous fish (catfish, zebrafish, scorpion fish, stonefish, cone shells, lionfish, sea urchins)
- Nematocysts (coral reef, fire coral, box jellyfish, sea wasp, portuguese man-of-war, sea anemones)
- Phylum porifera (sponges)
- Bites (alligator/crocodile, octopus, shark)
- Scorpion envenomation
- Reptile envenomation
- Spider bites
- Clinical Diagnosis
- Evaluate for compartment syndrome (see below)
- CBC, coags: Thrombocytopenia and elevated INR can occur in Crotaline envenomations.
- Remove all jewelry
- Mark the leading edge of erythema/edema
- Do not:
- Attempt to suck out the venom
- Place the affected part in cold water
- Use a tourniquet or wrap
- Antivenom is first line treatment for compartment syndrome; fasciotomy is last resort if elevated pressures persist.
- IVF and pressors if needed for hypotension
- Blood components rarely needed
- Treatment mainly depends upon the presence of an envenomation
- Always provide supportive care and treat local effects of any wounds
- Irrigation of the wound is necessary regardless of the type of snake bite
- Debridement and removal of devitalized tissue may be necessary for severe bites
- Evidence does not support use of empiric antibiotics to prevent secondary infection 
- Compartment syndrome has been documented with crotaline envenomation, but current literature does not support use of fasciotomy.  Treatment should focus on antivenom.
- All snake bites with evidence of envenomations should have a period of observation and possible hospitalization
- Old bites can be assessed and discharged if no evidence of envenomation.
- Seifert SA et al. AAPCC database characterization of native U.S. venomous snake exposures, 2001-2005. Clin Toxicol (Phila). 2009;47: 327–335.
- Goldfranks Toxicology - Envenomations
- Gold B.. Bites of venomous snakes. N Engl J Med. 2002;347(5):347-56.
- Cumpston KL. Is there a role for fasciotomy in Crotalinae envenomations in North America? PMID: 21740134