Ritonavir-boosted nirmatrelvir

Administration

• Type:
• Dosage Forms: Oral
• Routes of Administration:
• Common Trade Names: Paxlovid

Adult Dosing

COVID

• 300 mg nirmatrelvir with 100 mg ritonavir, twice daily for 5 days
  • Treatment of high risk patients with mild-to-moderate disease
  • Initiate within 5 days of symptom onset

Pediatric Dosing

COVID

• 300 mg nirmatrelvir with 100 mg ritonavir, twice daily for 5 days
  • 12 years of age and older weighing at least 40 kilograms
  • Treatment of high risk patients with mild-to-moderate disease
  • Initiate within 5 days of symptom onset

Special Populations

Renal Dosing

• Adult:
  • Renally dosed: if eGFR 30-60, then 150 mg/100 mg dosing
• Pediatric:

Hepatic Dosing

• Adult:
• Pediatric:

Contraindications

• Allergy to class/drug
  • Many drug interactions
  • E.g. Plavix, Phenytoin, Tacrolimus, Tramadol, Statins, Hydro/oxycodone/Codeine, Diazepam/Clonazepam/Alprazolam, Fentanyl, Tamsulosin

Pharmacology

• Half-life:
• Metabolism:
• Excretion:

Comments

• 89% reduction in hospitalization or death in high risk population, and 70% reduction in hospitalizations with no deaths in standard risk population.