Remi-fentanil
Administration
- Type: Synthetic opioid (ultra short acting)
- Routes of Administration: IV
- Common Trade Names: ULTIVA
Adult Dosing
- 1mcg/kg bolus for acute pain
- .25-5 mcg/kg/hr (titrate q20min) for maintenance analgesia
Pediatric Dosing
- 1mcg/kg bolus for acute pain
- .25-5 mcg/kg/hr (titrate q20min) for maintenance analgesia
Special Populations
Pregnancy Rating
- Prolonged use of opioid analgesics during pregnancy may cause neonatal opioid withdrawal syndrome
Lactation risk
- Risk is unknown
Renal Dosing
- Adult: Pharmacodynamics are not affected by renal dysfunction
- Pediatric: Pharmacodynamics are not affected by renal dysfunction
Hepatic Dosing
- Adult: Pharmacodynamics are not affected by liverdysfunction
- Pediatric: Pharmacodynamics are not affected by renal dysfunction
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Respiratory depression
Common
- Respiratory depression for large doses dependent on body weight.
Pharmacology
- Half-life: 1--20 min
- Metabolism: plasma and tissue esterases
- Excretion: NA
Mechanism of Action
Opiod mu receptor agonist that unlike other opioids is plasma metabolized irrespective of hepatic function.