Rasburicase

Administration

  • Type: Enzyme
  • Dosage Forms: Solution; 1.5mg & 7.5mg
  • Routes of Administration: IV
  • Common Trade Names: Elitek

Adult Dosing

  • Hyperuricemia due to tumor lysis syndrome: 0.2 mg/kg IV over 30 minutes daily for up to 5 days

Pediatric Dosing

  • 0.2 mg/kg IV over 30 minutes daily for up to 5 days

Special Populations

Contraindications

  • Allergy to class/drug
  • G6PD deficiency
  • History of hemolytic reaction to rasburicase or any excipients
  • History of methemoglobinemia reaction to rasburicase or any excipients

Adverse Reactions

Serious

  • Dysrhythmia, MI, heart failure, cardiac arrest
  • Bowel obstruction
  • Severe diarrhea, dehydration
  • Methemoglobinemia
  • Neutropenia, hemolysis, thrombocytopenia, pancytopenia
  • Hemorrhage, thrombosis
  • Sepsis
  • Stroke
  • Renal failure
  • Pulmonary edema, pulmonary hypertension, pneumonia, respiratory distress
  • Fever (severe), rigors

Common

  • Peripheral Edema
  • Fever
  • Rash
  • Diarrhea, nausea/vomiting, constipation, abdominal pain
  • Mucous membrane inflammation
  • Headache

Pharmacology

  • Half-life: 18h
  • Metabolism: liver
  • Excretion:

Mechanism of Action

  • Enzyme catalyzes oxidation of uric acid into inactive and soluble metabolite

Comments

See Also

References

Authors:

Claire