Ranitidine

General

  • Type: H2 blocker
  • Dosage Forms: 75, 150, 300
  • Common Trade Names: Zantac

Adult Dosing

GERD: 150mg PO BID

Pediatric Dosing

GERD: 5-10mg/kg/day PO BID

Special Populations

  • Pregnancy Rating: B
  • Lactation: Probably Safe
  • Renal Dosing
    • Adult: CrCl < 50: 150mg Qday; CrCl < 10: 75 -150mg Qday; HD: give dose after dialysis
    • Pediatric: CrCl < 10-50: decrease dose 50%; CrCl< 10: decrease dose 75%; HD: Give dose after dialysis
  • Hepatic Dosing
    • Adult: Not defined
    • Pediatric: not defined

Contraindications

  • Allergy to class/drug
  • Porphyria
  • Caution if impairment of liver or kidneys
  • Caution in chronic pulmonary disease
  • Caution if diabetes mellitus
  • Caution if immunocompromised

Adverse Reactions

Serious

Common

  • Nausea/vomiting/diarrhea
  • Fatigue
  • Headache
  • Rash
  • Myalgia
  • Xerostomia

Pharmacology

  • Half-life: 2-3 hr, Renal impairment: 5 hr
  • Metabolism: Liver
  • Excretion: Urine, Feces
  • Mechanism of Action: H2 blocker

See Also

References