Raltegravir

Administration

  • Type: Antiretroviral, Integrase inhibitor
  • Dosage Forms: 400 mg, 600 mg tablet
  • Routes of Administration: PO
  • Common Trade Names: Isentress

Adult Dosing

Recommended as part of a regimen including Tenofovir plus Emtricitabine or Lamivudine

  • Treatment-naive: 400 mg BID or 1200 mg daily
  • Treatment-experienced: 400 mg BID

Pediatric Dosing

Oral suspension (10 mg/mL): 6 mg/kg/dose BID

  • Maximum dose: 100 mg/dose

Special Populations

Renal Dosing

  • Mild to Moderate renal disease: No dosage adjustment necessary
  • ESRD on HD: Dose after dialysis on dialysis days

Hepatic Dosing

No dosage adjustment necessary

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

  • Hepatic- increased transaminases

Pharmacology

  • Half-life: 9 hours
  • Metabolism: Hepatic glucuronidation
  • Excretion: Renal

Mechanism of Action

  • Reverse transcriptase inhibitor

Comments

See Also

References

Authors:

Ross Donaldson