Pyrazinamide
Administration
- Type: Antibiotic, anti-TB
- Dosage Forms:
- Routes of Administration: Oral
- Common Trade Names:
Adult Dosing
- 40-55 kg: 1000mg PO daily OR 1500mg PO 3 times per week OR 2000mg PO 2 times per week in combination with other agents
- 56-75kg: 1500mg PO daily OR 2500mg PO 3 times per week OR 3000mg PO 2 times per week in combination with other agents
- 76-90kg: 2000mg PO daily OR 3000mg PO 3 times per week OR 4000mg PO 2 times per week in combination with other agents
Pediatric Dosing
- 15 to 30 mg/kg PO daily (max 2000mg/day) OR 50mg/kg PO 2 times per week in combination with other agents
Special Populations
- Pregnancy Rating: C
- Lactation risk: Infant risk cannot be ruled out
- Renal dosing, CrCl <30mL/min: 25-35mg/kg 3 times per week (after HD, if applicable)
- Hepatic dosing: contraindicated in severe liver damage
Contraindications
- Allergy to class/drug
- Severe hepatic damage
- Acute gout
Adverse Reactions
Serious
- Hepatotoxicity
- Anemia
Common
- Nausea/vomiting
- Arthralgia
- Hyperuricemia
Pharmacology
- Half-life: 6.7-12.3h, longer in cirrhosis and/or ESRD
- Metabolism: hepatic
- Excretion: Mostly renal
Mechanism of Action
- Nicotinamide analogue, exact antitubercular mechanism unknown