Prochlorperazine

General

  • Type: anti-psychotic and anti-emetic
  • Dosage Forms: 5, 10
  • Routes of Administration: IV, PO
  • Common Trade Names: Compazine

Adult Dosing

Headache

  • 10mg IV (slow push or in 1L IV NS)

Nausea/Vomiting

  • 5-10mg PO or IV q6-8 hours
  • Max: 40mg/day

Pediatric Dosing

nausea/vomiting, severe

2 yo and older, 9-14 kg

  • 2.5mg PO q12-24 h; Max 7.5mg/day

2 yo and older, 14-18 kg

  • 2.5mg PO q8-12 h; Max 10mg/day

2 yo and older, 18-39 kg

  • 2.5mg PO q8 hr; Max 15mg/day

2 yo and older, >39 kg

  • 5mg PO q6-8 h, Max: 20mg/day

Schizophrenia

2-5 yo

  • 2.5 - 5mg PO q6-8 hr, Max 20mg/day

6-12 yo

  • 2.5-5mg PO q6-8 hr, Max 25mg/day

Special Populations

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • tardive dyskinesia
  • neuroleptic malignant syndrome
  • blood dyscrasias
  • agranulocytosis
  • thrombocytopenic purpura
  • orthostatic hypotension
  • extrapyramidal symptoms
  • cholestatic jaundice
  • hepatotoxicity
  • QT prolongation
  • cardiac arrest
  • seizures
  • anaphylactoid reactions
  • lupus erythematosus
  • priapism
  • heat stroke
  • neonatal extrapyramidal symptoms (3rd trimester use)
  • neonatal withdrawal symptoms (3rd trimester use)

Common

  • drowsiness
  • dizziness
  • blurred vision
  • xerostomia
  • constipation
  • urinary retention
  • headache
  • nasal congestion
  • nausea
  • menstrual irregularities
  • amenorrhea
  • weight gain
  • hyperprolactinemia
  • hyperglycemia
  • hypoglycemia
  • insomnia
  • agitation
  • sexual dysfunction
  • photosensitivity
  • impaired body temperature regulation

Pharmacology

  • Half-life: 3-5 hrs (oral); 7 hrs (IV)
  • Metabolism: liver extensively, GI tract
  • Excretion: urine, bile/feces
  • Mechanism of Action: selectively antagonizes dopamine D2 receptors

Comments

See Also

References